Genetic modelling of PIM proteins in cancer: proviral tagging, cooperation with oncogenes, tumor suppressor genes and carcinogens.

Genetic modelling of PIM proteins in cancer: proviral tagging, cooperation with oncogenes, tumor suppressor genes and carcinogens.

The PIM proteins, which were initially discovered as proviral insertion sites in Moloney murine leukemia virus infection, are a family of highly homologous serine/threonine kinases that have been reported to be overexpressed in hematological malignancies and solid tumors. The PIM proteins have also...

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Bibliographic Details
Main Authors: Enara eAguirre, Oliver eRenner, Maja eNarlik-Grassow, Carmen eBlanco Aparicio
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-05-01
Series:Frontiers in Oncology
Subjects:
Carcinogens
tumors
transgenics
Pim kinases
proviral tagging
knock out
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00109/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00109/full

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