MYC overexpression and SMARCA4 loss cooperate to drive medulloblastoma formation in mice

MYC overexpression and SMARCA4 loss cooperate to drive medulloblastoma formation in mice

Abstract Group 3 medulloblastoma is one of the most aggressive types of childhood brain tumors. Roughly 30% of cases carry genetic alterations in MYC, SMARCA4, or both genes combined. While overexpression of MYC has previously been shown to drive medulloblastoma formation in mice, the functional sig...

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Bibliographic Details
Main Authors: Carolin Göbel, Shweta Godbole, Melanie Schoof, Dörthe Holdhof, Catena Kresbach, Carolin Loose, Julia Neumann, Ulrich Schüller
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Acta Neuropathologica Communications
Subjects:
Group 3 medulloblastoma
MYC
BRG1
BAF complex
Chromatin remodeling
Online Access:https://doi.org/10.1186/s40478-023-01654-2

Internet

https://doi.org/10.1186/s40478-023-01654-2

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