Mucus polymer concentration and in vivo adaptation converge to define the antibiotic response of Pseudomonas aeruginosa during chronic lung infection

Mucus polymer concentration and in vivo adaptation converge to define the antibiotic response of Pseudomonas aeruginosa during chronic lung infection

ABSTRACT The airway milieu of individuals with muco-obstructive airway diseases (MADs) is defined by the accumulation of dehydrated mucus due to hyperabsorption of airway surface liquid and defective mucociliary clearance. Pathological mucus becomes progressively more viscous with age and disease se...

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Bibliographic Details
Main Authors: Matthew A. Greenwald, Suzanne L. Meinig, Lucas M. Plott, Cristian Roca, Matthew G. Higgs, Nicholas P. Vitko, Matthew R. Markovetz, Kaitlyn R. Rouillard, Jerome Carpenter, Mehmet Kesimer, David B. Hill, Jonathan C. Schisler, Matthew C. Wolfgang
Format: Article
Language:English
Published: American Society for Microbiology 2024-06-01
Series:mBio
Subjects:
P. aeruginosa
tobramycin
antibiotic efficacy
sputum
muco-obstructive airway disease
Online Access:https://journals.asm.org/doi/10.1128/mbio.03451-23

Internet

https://journals.asm.org/doi/10.1128/mbio.03451-23

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