Development of lactate‐related gene signature and prediction of overall survival and chemosensitivity in patients with colorectal cancer
Abstract Background Colorectal cancer (CRC) is a malignant tumor of the digestive system that contains high levels of immune cells. Lactic acid, a major metabolite, plays a crucial role in tumor development, maintenance, and therapeutic response. However, the prognostic potential and therapeutic bio...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-04-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.5682 |
| _version_ | 1797831036591144960 |
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| author | Zhi Tong Xinyu Wang Sanbao Shi Tiewei Hou Guangrong Gao Da Li Yongqi Shan Cheng Zhang |
| author_facet | Zhi Tong Xinyu Wang Sanbao Shi Tiewei Hou Guangrong Gao Da Li Yongqi Shan Cheng Zhang |
| author_sort | Zhi Tong |
| collection | DOAJ |
| description | Abstract Background Colorectal cancer (CRC) is a malignant tumor of the digestive system that contains high levels of immune cells. Lactic acid, a major metabolite, plays a crucial role in tumor development, maintenance, and therapeutic response. However, the prognostic potential and therapeutic biomarker potential of lactate‐related genes (LRGs) in CRC patients remain to be elucidated. Methods We collected the mRNA expression profile and clinical data of CRC patients from the Cancer Genome Atlas (TCGA) database and the GSE59382 cohort. Univariate Cox regression, Lasso regression and multivariate Cox regression analysis were used to construct the prognosis model. Combined with the risk score and important clinicopathological features, the nomogram was established. In addition, the relationship between risk score and immune infiltration, immune checkpoint gene expression, and drug sensitivity was investigated. Results We constructed lactate‐related gene signatures (LRGS) based on four LRGs, which independently predicted the prognosis of CRC. Patients with different risk scores are found to have distinct immune status, tumor mutation load, immune response, and drug sensitivity. In addition, nomogram results determined by risk scores and clinical factors have higher predictive performance. Conclusion We found that LRGS is a reliable biomarker for predicting clinical outcomes, evaluating immune infiltration and efficacy, and predicting the sensitivity to drugs in patients with CRC. |
| first_indexed | 2024-04-09T13:45:38Z |
| format | Article |
| id | doaj.art-2350c6c4383944069038a03f4a392999 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-09T13:45:38Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-2350c6c4383944069038a03f4a3929992023-05-09T04:04:19ZengWileyCancer Medicine2045-76342023-04-01128101051012210.1002/cam4.5682Development of lactate‐related gene signature and prediction of overall survival and chemosensitivity in patients with colorectal cancerZhi Tong0Xinyu Wang1Sanbao Shi2Tiewei Hou3Guangrong Gao4Da Li5Yongqi Shan6Cheng Zhang7Department of General Surgery General Hospital of Northern Theater Command (Formerly Called General Hospital of Shenyang Military Area) Shenyang ChinaDepartment of General Surgery General Hospital of Northern Theater Command (Formerly Called General Hospital of Shenyang Military Area) Shenyang ChinaDepartment of General Surgery General Hospital of Northern Theater Command (Formerly Called General Hospital of Shenyang Military Area) Shenyang ChinaDepartment of General Surgery General Hospital of Northern Theater Command (Formerly Called General Hospital of Shenyang Military Area) Shenyang ChinaDepartment of General Surgery General Hospital of Northern Theater Command (Formerly Called General Hospital of Shenyang Military Area) Shenyang ChinaDepartment of General Surgery General Hospital of Northern Theater Command (Formerly Called General Hospital of Shenyang Military Area) Shenyang ChinaDepartment of General Surgery General Hospital of Northern Theater Command (Formerly Called General Hospital of Shenyang Military Area) Shenyang ChinaDepartment of General Surgery General Hospital of Northern Theater Command (Formerly Called General Hospital of Shenyang Military Area) Shenyang ChinaAbstract Background Colorectal cancer (CRC) is a malignant tumor of the digestive system that contains high levels of immune cells. Lactic acid, a major metabolite, plays a crucial role in tumor development, maintenance, and therapeutic response. However, the prognostic potential and therapeutic biomarker potential of lactate‐related genes (LRGs) in CRC patients remain to be elucidated. Methods We collected the mRNA expression profile and clinical data of CRC patients from the Cancer Genome Atlas (TCGA) database and the GSE59382 cohort. Univariate Cox regression, Lasso regression and multivariate Cox regression analysis were used to construct the prognosis model. Combined with the risk score and important clinicopathological features, the nomogram was established. In addition, the relationship between risk score and immune infiltration, immune checkpoint gene expression, and drug sensitivity was investigated. Results We constructed lactate‐related gene signatures (LRGS) based on four LRGs, which independently predicted the prognosis of CRC. Patients with different risk scores are found to have distinct immune status, tumor mutation load, immune response, and drug sensitivity. In addition, nomogram results determined by risk scores and clinical factors have higher predictive performance. Conclusion We found that LRGS is a reliable biomarker for predicting clinical outcomes, evaluating immune infiltration and efficacy, and predicting the sensitivity to drugs in patients with CRC.https://doi.org/10.1002/cam4.5682colorectal cancerimmunelactatenomogramprognostic signaturetumor microenvironment |
| spellingShingle | Zhi Tong Xinyu Wang Sanbao Shi Tiewei Hou Guangrong Gao Da Li Yongqi Shan Cheng Zhang Development of lactate‐related gene signature and prediction of overall survival and chemosensitivity in patients with colorectal cancer Cancer Medicine colorectal cancer immune lactate nomogram prognostic signature tumor microenvironment |
| title | Development of lactate‐related gene signature and prediction of overall survival and chemosensitivity in patients with colorectal cancer |
| title_full | Development of lactate‐related gene signature and prediction of overall survival and chemosensitivity in patients with colorectal cancer |
| title_fullStr | Development of lactate‐related gene signature and prediction of overall survival and chemosensitivity in patients with colorectal cancer |
| title_full_unstemmed | Development of lactate‐related gene signature and prediction of overall survival and chemosensitivity in patients with colorectal cancer |
| title_short | Development of lactate‐related gene signature and prediction of overall survival and chemosensitivity in patients with colorectal cancer |
| title_sort | development of lactate related gene signature and prediction of overall survival and chemosensitivity in patients with colorectal cancer |
| topic | colorectal cancer immune lactate nomogram prognostic signature tumor microenvironment |
| url | https://doi.org/10.1002/cam4.5682 |
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