Early 17β-estradiol treatment reduces seizures but not abnormal behaviour in mice with expanded polyalanine tracts in the Aristaless related homeobox gene (ARX)

Early 17β-estradiol treatment reduces seizures but not abnormal behaviour in mice with expanded polyalanine tracts in the Aristaless related homeobox gene (ARX)

Children with severe intellectual disability have an increased prevalence of refractory seizures. Steroid treatment may improve seizure outcomes, but the mechanism remains unknown. Here we demonstrate that short term, daily delivery of an exogenous steroid 17β-estradiol (40 ng/g) in early postnatal...

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Bibliographic Details
Main Authors: Karagh E. Loring, Tessa Mattiske, Kristie Lee, Aneta Zysk, Matilda R. Jackson, Jeffrey L. Noebels, Cheryl Shoubridge
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Neurobiology of Disease
Subjects:
Childhood epilepsy
Genetics: epilepsy
Genetics: learning disability
Epilepsy: co-morbidity
Molecular genetics
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121000784

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http://www.sciencedirect.com/science/article/pii/S0969996121000784

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