Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer’s disease

F1FO ATP synthase is a critical enzyme for the maintenance of mitochondrial function. Here the authors demonstrate that loss of the F1FO-ATP synthase subunit OSCP and the interaction of OSCP with Aβ peptide in Alzheimer’s disease patients and mouse models lead to F1FO-ATP synthase deregulation and d...

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Bibliographic Details
Main Authors: Simon J. Beck, Lan Guo, Aarron Phensy, Jing Tian, Lu Wang, Neha Tandon, Esha Gauba, Lin Lu, Juan M. Pascual, Sven Kroener, Heng Du
Format: Article
Language:English
Published: Nature Portfolio 2016-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11483