Differential effects of drug interventions and dietary lifestyle in developing type 2 diabetes and complications: a systems biology analysis in LDLr-/- mice.

Differential effects of drug interventions and dietary lifestyle in developing type 2 diabetes and complications: a systems biology analysis in LDLr-/- mice.

Excess caloric intake leads to metabolic overload and is associated with development of type 2 diabetes (T2DM). Current disease management concentrates on risk factors of the disease such as blood glucose, however with limited success. We hypothesize that normalizing blood glucose levels by itself i...

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Bibliographic Details
Main Authors: Marijana Radonjic, Peter Y Wielinga, Suzan Wopereis, Thomas Kelder, Varshna S Goelela, Lars Verschuren, Karin Toet, Wim van Duyvenvoorde, Bianca van der Werff van der Vat, Johanna H M Stroeve, Nicole Cnubben, Teake Kooistra, Ben van Ommen, Robert Kleemann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3574110?pdf=render

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http://europepmc.org/articles/PMC3574110?pdf=render

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