Integrative single-cell transcriptomic analyses reveal the cellular ontological and functional heterogeneities of primary and metastatic liver tumors

Integrative single-cell transcriptomic analyses reveal the cellular ontological and functional heterogeneities of primary and metastatic liver tumors

Abstract Background The global cellular landscape of the tumor microenvironment (TME) combining primary and metastatic liver tumors has not been comprehensively characterized. Methods Based on the scRNA-seq and spatial transcriptomic data of non-tumor liver tissues (NTs), primary liver tumors (PTs)...

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Bibliographic Details
Main Authors: Menghui Gui, Shilin Huang, Shizhou Li, Yuying Chen, Furong Cheng, Yulin Liu, Ji-ao Wang, Yuting Wang, Rui Guo, Yiming Lu, Pengbo Cao, Gangqiao Zhou
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Journal of Translational Medicine
Subjects:
Primary liver tumors
Metastatic liver tumors
Single-cell RNA sequencing
Tumor microenvironment
Ontological heterogeneity
Functional heterogeneity
Online Access:https://doi.org/10.1186/s12967-024-04947-9

Internet

https://doi.org/10.1186/s12967-024-04947-9

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