Nuclear-encoded factors involved in post-transcriptional processing and modification of mitochondrial tRNAs in human disease

Nuclear-encoded factors involved in post-transcriptional processing and modification of mitochondrial tRNAs in human disease

The human mitochondrial genome (mtDNA) encodes twenty-two tRNAs (mt-tRNAs) that are necessary for the intraorganellar translation of the thirteen mtDNA-encoded subunits of the mitochondrial respiratory chain complexes. Maturation of mt-tRNAs involves 5’ and 3’ nucleolytic excision from precursor RNA...

Full description

Bibliographic Details
Main Authors: Christopher A Powell, Thomas J Nicholls, Michal eMinczuk
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Genetics
Subjects:
Mitochondria
RNA processing
tRNA
RNA modification
mitochondrial disease
Post-tran
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00079/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00079/full

Similar Items