Combination Therapy with Oseltamivir and Favipiravir Delays Mortality but Does Not Prevent Oseltamivir Resistance in Immunodeficient Mice Infected with Pandemic A(H1N1) Influenza Virus

Combination Therapy with Oseltamivir and Favipiravir Delays Mortality but Does Not Prevent Oseltamivir Resistance in Immunodeficient Mice Infected with Pandemic A(H1N1) Influenza Virus

Immunosuppressed individuals can shed influenza virus for prolonged periods of time, leading to the frequent emergence of antiviral resistance. We evaluated the benefits of oseltamivir and favipiravir combination therapy compared to single antiviral agents and monitored the emergence of drug-resista...

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Bibliographic Details
Main Authors: Mariana Baz, Julie Carbonneau, Chantal Rhéaume, Marie-Hélène Cavanagh, Guy Boivin
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Viruses
Subjects:
pandemic influenza virus
immunosuppression
combination therapy
oseltamivir
favipiravir
resistance
mice
Online Access:https://www.mdpi.com/1999-4915/10/11/610

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https://www.mdpi.com/1999-4915/10/11/610

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