Phillyrin Attenuates Osteoclast Formation and Function and Prevents LPS-Induced Osteolysis in Mice

Phillyrin Attenuates Osteoclast Formation and Function and Prevents LPS-Induced Osteolysis in Mice

As the sole cell type responsible for bone resorption, osteoclasts play a pivotal role in a variety of lytic bone diseases. Suppression of osteoclast formation and activation has been proposed as an effective protective therapy for new bone. In this study, we reported for the first time that phillyr...

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Bibliographic Details
Main Authors: Jing Wang, Gang Chen, Qianqian Zhang, Fuli Zhao, Xiaolu Yu, Xuemei Ma, Mei Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Pharmacology
Subjects:
phillyrin
osteoclast formation
bone resorption
MAPK signaling pathway
osteolysis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01188/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01188/full

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