Phillyrin Attenuates Osteoclast Formation and Function and Prevents LPS-Induced Osteolysis in Mice
As the sole cell type responsible for bone resorption, osteoclasts play a pivotal role in a variety of lytic bone diseases. Suppression of osteoclast formation and activation has been proposed as an effective protective therapy for new bone. In this study, we reported for the first time that phillyr...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-10-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2019.01188/full |
| _version_ | 1818035186391056384 |
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| author | Jing Wang Gang Chen Qianqian Zhang Fuli Zhao Xiaolu Yu Xuemei Ma Mei Liu |
| author_facet | Jing Wang Gang Chen Qianqian Zhang Fuli Zhao Xiaolu Yu Xuemei Ma Mei Liu |
| author_sort | Jing Wang |
| collection | DOAJ |
| description | As the sole cell type responsible for bone resorption, osteoclasts play a pivotal role in a variety of lytic bone diseases. Suppression of osteoclast formation and activation has been proposed as an effective protective therapy for new bone. In this study, we reported for the first time that phillyrin (Phil), an active ingredient extracted from forsythia, significantly inhibited RANKL-induced osteoclastogenesis and bone resorption in vitro and protected against lipopolysaccharide-induced osteolysis in vivo. Further molecular investigations demonstrated that Phil effectively blocked RANKL-induced activations of c-Jun N-terminal kinase and extracellular signal-regulated kinase, which suppressed the expression of c-Fos and nuclear factor of activated T-cells cytoplasmic 1. Taken together, these data suggested that Phil might be a potential antiosteoclastogenesis agent for treating osteoclast-related bone lytic diseases. |
| first_indexed | 2024-12-10T06:51:03Z |
| format | Article |
| id | doaj.art-235a6c37b63d4998a72a206c2bf112d6 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-10T06:51:03Z |
| publishDate | 2019-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-235a6c37b63d4998a72a206c2bf112d62022-12-22T01:58:32ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122019-10-011010.3389/fphar.2019.01188470586Phillyrin Attenuates Osteoclast Formation and Function and Prevents LPS-Induced Osteolysis in MiceJing WangGang ChenQianqian ZhangFuli ZhaoXiaolu YuXuemei MaMei LiuAs the sole cell type responsible for bone resorption, osteoclasts play a pivotal role in a variety of lytic bone diseases. Suppression of osteoclast formation and activation has been proposed as an effective protective therapy for new bone. In this study, we reported for the first time that phillyrin (Phil), an active ingredient extracted from forsythia, significantly inhibited RANKL-induced osteoclastogenesis and bone resorption in vitro and protected against lipopolysaccharide-induced osteolysis in vivo. Further molecular investigations demonstrated that Phil effectively blocked RANKL-induced activations of c-Jun N-terminal kinase and extracellular signal-regulated kinase, which suppressed the expression of c-Fos and nuclear factor of activated T-cells cytoplasmic 1. Taken together, these data suggested that Phil might be a potential antiosteoclastogenesis agent for treating osteoclast-related bone lytic diseases.https://www.frontiersin.org/article/10.3389/fphar.2019.01188/fullphillyrinosteoclast formationbone resorptionMAPK signaling pathwayosteolysis |
| spellingShingle | Jing Wang Gang Chen Qianqian Zhang Fuli Zhao Xiaolu Yu Xuemei Ma Mei Liu Phillyrin Attenuates Osteoclast Formation and Function and Prevents LPS-Induced Osteolysis in Mice Frontiers in Pharmacology phillyrin osteoclast formation bone resorption MAPK signaling pathway osteolysis |
| title | Phillyrin Attenuates Osteoclast Formation and Function and Prevents LPS-Induced Osteolysis in Mice |
| title_full | Phillyrin Attenuates Osteoclast Formation and Function and Prevents LPS-Induced Osteolysis in Mice |
| title_fullStr | Phillyrin Attenuates Osteoclast Formation and Function and Prevents LPS-Induced Osteolysis in Mice |
| title_full_unstemmed | Phillyrin Attenuates Osteoclast Formation and Function and Prevents LPS-Induced Osteolysis in Mice |
| title_short | Phillyrin Attenuates Osteoclast Formation and Function and Prevents LPS-Induced Osteolysis in Mice |
| title_sort | phillyrin attenuates osteoclast formation and function and prevents lps induced osteolysis in mice |
| topic | phillyrin osteoclast formation bone resorption MAPK signaling pathway osteolysis |
| url | https://www.frontiersin.org/article/10.3389/fphar.2019.01188/full |
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