The Interaction of HMGB1 with the Proinflammatory TREM-1 Receptor Generates Cytotoxic Lymphocytes Active against HLA-Negative Tumor Cells

The Interaction of HMGB1 with the Proinflammatory TREM-1 Receptor Generates Cytotoxic Lymphocytes Active against HLA-Negative Tumor Cells

High mobility group protein (HMGB1) is secreted by myeloid cells and cells of damaged tissues during inflammation, causing inflammatory reactions through various receptors, including TLR<sub>S</sub> and RAGE. TREM-1 is considered to be one of the potential HMGB1 receptors. In this work,...

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Bibliographic Details
Main Authors: Daria M. Yurkina, Elena A. Romanova, Alexey V. Feoktistov, Natalia V. Soshnikova, Anna V. Tvorogova, Denis V. Yashin, Lidia P. Sashchenko
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:International Journal of Molecular Sciences
Subjects:
HMGB1
TREM-1
cytotoxic lymphocytes
HLA-negative tumor cells
apoptosis
necroptosis
Online Access:https://www.mdpi.com/1422-0067/25/1/627

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https://www.mdpi.com/1422-0067/25/1/627

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