hNGF Peptides Elicit the NGF-TrkA Signalling Pathway in Cholinergic Neurons and Retain Full Neurotrophic Activity in the DRG Assay

hNGF Peptides Elicit the NGF-TrkA Signalling Pathway in Cholinergic Neurons and Retain Full Neurotrophic Activity in the DRG Assay

In the last decade, Nerve Growth Factor (NGF)-based clinical approaches have lacked specific and efficient Tyrosine Kinase A (TrkA) agonists for brain delivery. Nowadays, the characterization of novel small peptidomimetic is taking centre stage in preclinical studies, in order to overcome the main s...

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Bibliographic Details
Main Authors: Viviana Triaca, Elena Fico, Valentina Sposato, Silvia Caioli, Maria Teresa Ciotti, Cristina Zona, Delio Mercanti, Diego La Mendola, Cristina Satriano, Enrico Rizzarelli, Paola Tirassa, Pietro Calissano
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Biomolecules
Subjects:
ngf mimetic
hngf1–14
trka agonist
cholinergic neurons
drg
neurotrophic therapy
Online Access:https://www.mdpi.com/2218-273X/10/2/216

Internet

https://www.mdpi.com/2218-273X/10/2/216

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