Elevated serum polyclonal immunoglobulin free light chains in patients with severe asthma

Elevated serum polyclonal immunoglobulin free light chains in patients with severe asthma

Background: Inflammation plays a pivotal role in the pathophysiology of asthma. Free light chains (FLC) can cause inflammation by mast cell antigen-activation. Serum immunoglobulin (Ig) FLC κ, but not λ, were shown elevated in adult males with asthma. We sought to investigate if serum Ig FLC concent...

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Bibliographic Details
Main Authors: Umberto Basile, Giuseppe Santini, Cecilia Napodano, Giuseppe Macis, Krizia Pocino, Francesca Gulli, Mario Malerba, Andrew Bush, Ian M. Adcock, Paolo Montuschi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Pharmacology
Subjects:
asthma
inflammation
free light chains
biomarkers
personalised medicine
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1126535/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1126535/full

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