Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA

Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA

Abstract Background Although effective in reducing relapse rate and delaying progression, current therapies for multiple sclerosis (MS) do not completely halt disease progression. T cell autoimmunity to myelin antigens is considered one of the main mechanisms driving MS. It is characterized by autor...

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Main Authors: Judith Derdelinckx, María José Mansilla, Maxime De Laere, Wai-Ping Lee, Juan Navarro-Barriuso, Inez Wens, Irene Nkansah, Jasmijn Daans, Hans De Reu, Aneta Jolanta Keliris, Johan Van Audekerke, Verdi Vanreusel, Zoë Pieters, Annemie Van der Linden, Marleen Verhoye, Geert Molenberghs, Niel Hens, Herman Goossens, Barbara Willekens, Patrick Cras, Peter Ponsaerts, Zwi N. Berneman, Eva María Martínez-Cáceres, Nathalie Cools
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Journal of Neuroinflammation
Subjects:
Messenger RNA electroporation
Tolerogenic dendritic cells
Antigen-specific treatment
Experimental autoimmune encephalomyelitis
Multiple sclerosis
Tolerance induction
Online Access:http://link.springer.com/article/10.1186/s12974-019-1541-1

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http://link.springer.com/article/10.1186/s12974-019-1541-1

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