Retinoic acid modulation guides human-induced pluripotent stem cell differentiation towards left or right ventricle-like cardiomyocytes

Retinoic acid modulation guides human-induced pluripotent stem cell differentiation towards left or right ventricle-like cardiomyocytes

Abstract Background Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) by traditional methods are a mix of atrial and ventricular CMs and many other non-cardiomyocyte cells. Retinoic acid (RA) plays an important role in regulation of the spatiotemporal development of the...

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Bibliographic Details
Main Authors: Hengliang Zhang, Payel Sen, Jules Hamers, Theresa Sittig, Brent Woestenburg, Allessandra Moretti, Andreas Dendorfer, Daphne Merkus
Format: Article
Language:English
Published: BMC 2024-06-01
Series:Stem Cell Research & Therapy
Subjects:
Retinoic acid
hiPSC
Cardiomyocyte
Engineered heart tissue
Left ventricle
Online Access:https://doi.org/10.1186/s13287-024-03741-0

Internet

https://doi.org/10.1186/s13287-024-03741-0

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