Cationic lipid-formulated DNA vaccine against hepatitis B virus: immunogenicity of MIDGE-Th1 vectors encoding small and large surface antigen in comparison to a licensed protein vaccine.

Cationic lipid-formulated DNA vaccine against hepatitis B virus: immunogenicity of MIDGE-Th1 vectors encoding small and large surface antigen in comparison to a licensed protein vaccine.

Currently marketed vaccines against hepatitis B virus (HBV) based on the small (S) hepatitis B surface antigen (HBsAg) fail to induce a protective immune response in about 10% of vaccinees. DNA vaccination and the inclusion of PreS1 and PreS2 domains of HBsAg have been reported to represent feasible...

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Bibliographic Details
Main Authors: Anne Endmann, Katharina Klünder, Kerstin Kapp, Oliver Riede, Detlef Oswald, Eduard G Talman, Matthias Schroff, Christiane Kleuss, Marcel H J Ruiters, Christiane Juhls
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4081723?pdf=render

Internet

http://europepmc.org/articles/PMC4081723?pdf=render

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