Induction of Breast Cancer Cell Apoptosis by TRAIL and Smac Mimetics: Involvement of RIP1 and cFLIP

Induction of Breast Cancer Cell Apoptosis by TRAIL and Smac Mimetics: Involvement of RIP1 and cFLIP

Smac mimetics are a group of compounds able to facilitate cell death in cancer cells. TNF-related apoptosis-inducing ligand (TRAIL) is a death receptor ligand currently explored in combination with Smac mimetics. The molecular mechanisms determining if the combination treatment results in apoptosis...

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Bibliographic Details
Main Authors: Christian Holmgren, Ellen Sunström Thörnberg, Victoria Granqvist, Christer Larsson
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Current Issues in Molecular Biology
Subjects:
Smac mimetic
TRAIL
apoptosis
breast cancer
c-FLIP
RIP1
Online Access:https://www.mdpi.com/1467-3045/44/10/327

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https://www.mdpi.com/1467-3045/44/10/327

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