Comparison of chemical-induced temporomandibular osteoarthritis rat models (monosodium iodoacetate versus collagenase type II) for the study of prolonged drug delivery systems
<h4>Objective</h4> To compare two agents that can induce a rat model of temporomandibular joint osteoarthritis (TMJOA) by chemical induction: monosodium iodoacetate (MIA) and collagenase type 2 (Col-2). We wished to ascertain the best agent for assessing drug-delivery systems (DDSs). <...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888674/?tool=EBI |
| _version_ | 1811173520429809664 |
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| author | Florent Barry Feng Chai Henry Chijcheapaza-Flores Maria José Garcia-Fernandez Nicolas Blanchemain Romain Nicot |
| author_facet | Florent Barry Feng Chai Henry Chijcheapaza-Flores Maria José Garcia-Fernandez Nicolas Blanchemain Romain Nicot |
| author_sort | Florent Barry |
| collection | DOAJ |
| description | <h4>Objective</h4> To compare two agents that can induce a rat model of temporomandibular joint osteoarthritis (TMJOA) by chemical induction: monosodium iodoacetate (MIA) and collagenase type 2 (Col-2). We wished to ascertain the best agent for assessing drug-delivery systems (DDSs). <h4>Method</h4> Male Wistar rats underwent intra-articular injection with MIA or Col-2. They were manipulated for 30 days. The head withdrawal threshold (HWT), immunohistological assessment, and positron emission tomography (PET) were used to evaluate the relevance of our models. <h4>Results</h4> For both the MIA and Col-2 groups, pain persisted for 30 days after injection. Change in the HWT showed that Col-2 elicited a strong action initially that decreased progressively. MIA had a constant action upon pain behavior. Histology of TMJ tissue from both groups showed progressive degradation of TMJ components. <h4>Conclusions</h4> MIA and Col-2 induced orofacial pain by their local chemical action on TMJs. However, based on a prolonged and greater sustained effect on the pain threshold, persistent histological changes, and imaging results, MIA appeared to be more suitable for creation of a rat model of TMJOA for the study of DDSs. |
| first_indexed | 2024-04-10T17:48:22Z |
| format | Article |
| id | doaj.art-237110aa2a4d4de58faabf42b6f44b00 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-10T17:48:22Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-237110aa2a4d4de58faabf42b6f44b002023-02-02T22:58:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01181Comparison of chemical-induced temporomandibular osteoarthritis rat models (monosodium iodoacetate versus collagenase type II) for the study of prolonged drug delivery systemsFlorent BarryFeng ChaiHenry Chijcheapaza-FloresMaria José Garcia-FernandezNicolas BlanchemainRomain Nicot<h4>Objective</h4> To compare two agents that can induce a rat model of temporomandibular joint osteoarthritis (TMJOA) by chemical induction: monosodium iodoacetate (MIA) and collagenase type 2 (Col-2). We wished to ascertain the best agent for assessing drug-delivery systems (DDSs). <h4>Method</h4> Male Wistar rats underwent intra-articular injection with MIA or Col-2. They were manipulated for 30 days. The head withdrawal threshold (HWT), immunohistological assessment, and positron emission tomography (PET) were used to evaluate the relevance of our models. <h4>Results</h4> For both the MIA and Col-2 groups, pain persisted for 30 days after injection. Change in the HWT showed that Col-2 elicited a strong action initially that decreased progressively. MIA had a constant action upon pain behavior. Histology of TMJ tissue from both groups showed progressive degradation of TMJ components. <h4>Conclusions</h4> MIA and Col-2 induced orofacial pain by their local chemical action on TMJs. However, based on a prolonged and greater sustained effect on the pain threshold, persistent histological changes, and imaging results, MIA appeared to be more suitable for creation of a rat model of TMJOA for the study of DDSs.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888674/?tool=EBI |
| spellingShingle | Florent Barry Feng Chai Henry Chijcheapaza-Flores Maria José Garcia-Fernandez Nicolas Blanchemain Romain Nicot Comparison of chemical-induced temporomandibular osteoarthritis rat models (monosodium iodoacetate versus collagenase type II) for the study of prolonged drug delivery systems PLoS ONE |
| title | Comparison of chemical-induced temporomandibular osteoarthritis rat models (monosodium iodoacetate versus collagenase type II) for the study of prolonged drug delivery systems |
| title_full | Comparison of chemical-induced temporomandibular osteoarthritis rat models (monosodium iodoacetate versus collagenase type II) for the study of prolonged drug delivery systems |
| title_fullStr | Comparison of chemical-induced temporomandibular osteoarthritis rat models (monosodium iodoacetate versus collagenase type II) for the study of prolonged drug delivery systems |
| title_full_unstemmed | Comparison of chemical-induced temporomandibular osteoarthritis rat models (monosodium iodoacetate versus collagenase type II) for the study of prolonged drug delivery systems |
| title_short | Comparison of chemical-induced temporomandibular osteoarthritis rat models (monosodium iodoacetate versus collagenase type II) for the study of prolonged drug delivery systems |
| title_sort | comparison of chemical induced temporomandibular osteoarthritis rat models monosodium iodoacetate versus collagenase type ii for the study of prolonged drug delivery systems |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9888674/?tool=EBI |
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