Contraction of human brain vascular pericytes in response to islet amyloid polypeptide is reversed by pramlintide

Contraction of human brain vascular pericytes in response to islet amyloid polypeptide is reversed by pramlintide

Abstract The islet amyloid polypeptide (IAPP), a pancreas-produced peptide, has beneficial functions in its monomeric form. However, IAPP aggregates, related to type 2 diabetes mellitus (T2DM), are toxic not only for the pancreas, but also for the brain. In the latter, IAPP is often found in vessels...

Full description

Bibliographic Details
Main Authors: Cristina Nuñez-Diaz, Dovilė Pocevičiūtė, Nina Schultz, The Netherlands Brain Bank, Charlotte Welinder, Karl Swärd, Malin Wennström
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Molecular Brain
Subjects:
Amylin
Vasculopathy
Mural cells
Diabetes
Blood flow
Online Access:https://doi.org/10.1186/s13041-023-01013-1

Internet

https://doi.org/10.1186/s13041-023-01013-1

Similar Items