Epigenetic and transcriptome responsiveness to ER modulation by tissue selective estrogen complexes in breast epithelial and breast cancer cells.

Epigenetic and transcriptome responsiveness to ER modulation by tissue selective estrogen complexes in breast epithelial and breast cancer cells.

Selective estrogen receptor modulators (SERMs), including the SERM/SERD bazedoxifene (BZA), are used to treat postmenopausal osteoporosis and may reduce breast cancer (BCa) risk. One of the most persistent unresolved questions regarding menopausal hormone therapy is compromised control of proliferat...

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Bibliographic Details
Main Authors: Terri L Messier, Joseph R Boyd, Jonathan A R Gordon, Coralee E Tye, Natalie A Page, Rabail H Toor, Sayyed K Zaidi, Barry S Komm, Seth Frietze, Janet L Stein, Jane B Lian, Gary S Stein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0271725

Internet

https://doi.org/10.1371/journal.pone.0271725

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