CD73, a Promising Therapeutic Target of Diclofenac, Promotes Metastasis of Pancreatic Cancer through a Nucleotidase Independent Mechanism

CD73, a Promising Therapeutic Target of Diclofenac, Promotes Metastasis of Pancreatic Cancer through a Nucleotidase Independent Mechanism

Abstract CD73, a cell surface‐bound nucleotidase, facilitates extracellular adenosine formation by hydrolyzing 5′‐AMP to adenosine. Several studies have shown that CD73 plays an essential role in immune escape, cell proliferation and tumor angiogenesis, making it an attractive target for cancer ther...

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Bibliographic Details
Main Authors: Weishuai Liu, Xiaozhou Yu, Yudong Yuan, Yixing Feng, Chao Wu, Chongbiao Huang, Peng Xie, Shengnan Li, Xiaofeng Li, Ziyang Wang, Lisha Qi, Yanan Chen, Lei Shi, Mulin Jun Li, Zhiyong Huang, Bo Tang, Antao Chang, Jihui Hao
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:Advanced Science
Subjects:
CD73
diclofenac
epithelial‐mesenchymal‐transitions
metastasis
pancreatic ductal adenocarcinoma
Online Access:https://doi.org/10.1002/advs.202206335

Internet

https://doi.org/10.1002/advs.202206335

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