Discovery of a Novel Acetylcholinesterase Inhibitor by Fragment-Based Design and Virtual Screening

Discovery of a Novel Acetylcholinesterase Inhibitor by Fragment-Based Design and Virtual Screening

Despite extensive and intensive research efforts in recent decades, there is still no effective treatment for neurodegenerative diseases. On this background, the use of drugs inhibiting the enzyme acetylcholinesterase (AChE) remains an eternal evergreen in the symptomatic treatment of mild to modera...

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Bibliographic Details
Main Authors: Georgi Stavrakov, Irena Philipova, Atanas Lukarski, Mariyana Atanasova, Borislav Georgiev, Teodora Atanasova, Spiro Konstantinov, Irini Doytchinova
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Molecules
Subjects:
acetylcholinesterase inhibitor
fragment-based library
molecular docking
BBB permeability
galantamine
neurotoxicity
Online Access:https://www.mdpi.com/1420-3049/26/7/2058

Internet

https://www.mdpi.com/1420-3049/26/7/2058

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