Efficient Synthesis of β-Aryl-γ-lactams and Their Resolution with (S)-Naproxen: Preparation of (R)- and (S)-Baclofen

Efficient Synthesis of β-Aryl-γ-lactams and Their Resolution with (S)-Naproxen: Preparation of (R)- and (S)-Baclofen

An efficient synthesis of enantiomerically-pure β-aryl-γ-lactams is described. The principal feature of this synthesis is the practical resolution of β-aryl-γ-lactams with (S)-Naproxen. The procedure is based on the Michael addition of nitromethane to benzylidenemalonates, which was easily obtained,...

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Bibliographic Details
Main Authors: Iris J. Montoya-Balbás, Berenice Valentín-Guevara, Estefanía López-Mendoza, Irma Linzaga-Elizalde, Mario Ordoñez, Perla Román-Bravo
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Molecules
Subjects:
β-aryl-γ-lactams
Michael addition
resolution
(S)-naproxen
baclofen
phenibut
Online Access:http://www.mdpi.com/1420-3049/20/12/19830

Internet

http://www.mdpi.com/1420-3049/20/12/19830

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