Targeting KAT2A inhibits inflammatory macrophage activation and rheumatoid arthritis through epigenetic and metabolic reprogramming

Targeting KAT2A inhibits inflammatory macrophage activation and rheumatoid arthritis through epigenetic and metabolic reprogramming

Abstract Epigenetic regulation of inflammatory macrophages governs inflammation initiation and resolution in the pathogenesis of rheumatoid arthritis (RA). Nevertheless, the mechanisms underlying macrophage‐mediated arthritis injuries remain largely obscure. Here, we found that increased expression...

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Bibliographic Details
Main Authors: Yunkai Zhang, Ying Gao, Yingying Ding, Yuyu Jiang, Huiying Chen, Zhenzhen Zhan, Xingguang Liu
Format: Article
Language:English
Published: Wiley 2023-06-01
Series:MedComm
Subjects:
KAT2A
metabolic reprogramming
NLRP3
NRF2
rheumatoid arthritis
Online Access:https://doi.org/10.1002/mco2.306

Internet

https://doi.org/10.1002/mco2.306

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