Cytosine arabinoside exposure induced cytotoxic effects and neural tube defects in mice and embryo stem cells

Cytosine arabinoside (Ara-C) is one of the most widely used chemotherapeutic agents for hematological malignancies. The residues of Ara-C have been detected in wastewater and river water with increased usage and discharge. As the ability to cross the placenta and the teratogenicity at low ng/L level...

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Bibliographic Details
Main Authors: Zhen Guan, Yingchao Liang, Zhiqiang Zhu, Aiyun Yang, Shen Li, Jin Guo, Fang Wang, Huimin Yang, Na Zhang, Xiuwei Wang, Jianhua Wang
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651323006450