IMT504 protects beta cells against apoptosis and maintains beta cell identity, without modifying proliferation

IMT504 protects beta cells against apoptosis and maintains beta cell identity, without modifying proliferation

Abstract We have demonstrated that oligodeoxynucleotide IMT504 promotes significant improvement in the diabetic condition in diverse animal models. Based on these results, here we evaluated whether these effects observed in vivo could be due to direct effects on β‐cells. We demonstrate by immunofluo...

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Bibliographic Details
Main Authors: Ayelén Converti, María Silvia Bianchi, Mario D. Martinez, Alejandro D. Montaner, Victoria Lux‐Lantos, María Marta Bonaventura
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:Physiological Reports
Subjects:
apoptosis
oligodeoxynucleotides
proliferation
transcription factors
β‐Cells
Online Access:https://doi.org/10.14814/phy2.15790

Internet

https://doi.org/10.14814/phy2.15790

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