Quillaja saponin mitigates methotrexate-provoked renal injury; insight into Nrf-2/Keap-1 pathway modulation with suppression of oxidative stress and inflammation

Quillaja saponin mitigates methotrexate-provoked renal injury; insight into Nrf-2/Keap-1 pathway modulation with suppression of oxidative stress and inflammation

Abstract Background Methotrexate (MTX) is an antineoplastic/immunosuppressive drug, whose clinical use is impeded owing to its serious adverse effects; one of which is acute kidney injury (AKI). Most of MTX complications emerged from the provoked pro-oxidant-, pro-inflammatory- and pro-apoptotic eff...

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Bibliographic Details
Main Authors: Mustafa Ahmed Abdel-Reheim, Merhan E. Ali, Ahmed Gaafar A. Gaafar, Ahmed Amine Ashour
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Journal of Pharmaceutical Health Care and Sciences
Subjects:
Quillaja saponaria
Methotrexate
Pathological kidney
Oxidative stress
Apoptosis
TNF-α/Nrf-2/Keap-1
Online Access:https://doi.org/10.1186/s40780-024-00330-4

Internet

https://doi.org/10.1186/s40780-024-00330-4

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