SIRT1 Prevents R-Loops during Chronological Aging by Modulating DNA Replication at rDNA Loci

SIRT1 Prevents R-Loops during Chronological Aging by Modulating DNA Replication at rDNA Loci

In metazoans, the largest sirtuin, SIRT1, is a nuclear protein implicated in epigenetic modifications, circadian signaling, DNA recombination, replication, and repair. Our previous studies have demonstrated that SIRT1 binds replication origins and inhibits replication initiation from a group of pote...

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Bibliographic Details
Main Authors: Bhushan L. Thakur, Nana A. Kusi, Sara Mosavarpour, Roger Zhu, Christophe E. Redon, Haiqing Fu, Anjali Dhall, Lorinc S. Pongor, Robin Sebastian, Fred E. Indig, Mirit I. Aladjem
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Cells
Subjects:
aging
cancer
chromatin
genomic stability
Online Access:https://www.mdpi.com/2073-4409/12/22/2630

Internet

https://www.mdpi.com/2073-4409/12/22/2630

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