Synthesis and Evaluation of <sup>177</sup>Lu-DOTA-PD-L1-i and <sup>225</sup>Ac-HEHA-PD-L1-i as Potential Radiopharmaceuticals for Tumor Microenvironment-Targeted Radiotherapy

Synthesis and Evaluation of <sup>177</sup>Lu-DOTA-PD-L1-i and <sup>225</sup>Ac-HEHA-PD-L1-i as Potential Radiopharmaceuticals for Tumor Microenvironment-Targeted Radiotherapy

Current cancer therapies focus on reducing immunosuppression and remodeling the tumor microenvironment to inhibit metastasis, cancer progression, and therapeutic resistance. Programmed death receptor 1 (PD-1) is expressed on immune T cells and is one of the so-called checkpoint proteins that can sup...

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Bibliographic Details
Main Authors: Myrna Luna-Gutiérrez, Pedro Cruz-Nova, Nallely Jiménez-Mancilla, Rigoberto Oros-Pantoja, Nancy Lara-Almazán, Clara Santos-Cuevas, Erika Azorín-Vega, Blanca Ocampo-García, Guillermina Ferro-Flores
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
PD-L1 radioinhibitors
actinium-225
lutetium-177
targeted radiotherapy
Online Access:https://www.mdpi.com/1422-0067/24/15/12382

Internet

https://www.mdpi.com/1422-0067/24/15/12382

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