Lineage plasticity and treatment resistance in prostate cancer: the intersection of genetics, epigenetics, and evolution

Lineage plasticity and treatment resistance in prostate cancer: the intersection of genetics, epigenetics, and evolution

Androgen deprivation therapy is a cornerstone of treatment for advanced prostate cancer, and the development of castrate-resistant prostate cancer (CRPC) is the primary cause of prostate cancer-related mortality. While CRPC typically develops through a gain in androgen receptor (AR) signaling, a sub...

Full description

Bibliographic Details
Main Authors: Jarrell Imamura, Shinjini Ganguly, Andrew Muskara, Ross S. Liao, Jane K. Nguyen, Christopher Weight, Christopher E. Wee, Shilpa Gupta, Omar Y. Mian
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Endocrinology
Subjects:
neuroendocrine prostate cancer
lineage plasticity
epigenetic dysregulation
hormone therapy resistance
radioresistance
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1191311/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2023.1191311/full

Similar Items