Pharmaceutical Composition of Valsartan: β-Cyclodextrin: Physico–Chemical Characterization and Anti-Hypertensive Evaluation

Pharmaceutical Composition of Valsartan: β-Cyclodextrin: Physico–Chemical Characterization and Anti-Hypertensive Evaluation

Valsartan, a water-insoluble drug, is mainly used in the treatment of hypertension albeit with reduced oral bioavailability. The aim of work was to develop a valsartan:β-cyclodextrin (VAL:β-CD) pharmaceutical composition in order to improve its water solubility and bioavailability. The VAL:β-CD comp...

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Bibliographic Details
Main Authors: Carlos Eduardo de Matos Jensen, Robson Augusto Souza dos Santos, Angelo Márcio Leite Denadai, Cynthia Fernandes Ferreira Santos, Aline Nardoni Gonçalves Braga, Rubén Dario Sinisterra
Format: Article
Language:English
Published: MDPI AG 2010-06-01
Series:Molecules
Subjects:
valsartan
β-cyclodextrin
intrinsic dissolution
ROESY
anti-hypertensive evaluation
Online Access:http://www.mdpi.com/1420-3049/15/6/4067/

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http://www.mdpi.com/1420-3049/15/6/4067/

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