CAR-iNKT cells targeting clonal TCRVβ chains as a precise strategy to treat T cell lymphoma

CAR-iNKT cells targeting clonal TCRVβ chains as a precise strategy to treat T cell lymphoma

IntroductionMost T cell receptor (TCR)Vβ chain-expressing T cell lymphomas (TCL) including those caused by Human T cell leukaemia virus type-1 (HTLV-1) have poor prognosis. We hypothesised that chimeric antigen receptor (CAR)-mediated targeting of the clonal, lymphoma-associated TCRβ chains would co...

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Bibliographic Details
Main Authors: Aileen G. Rowan, Kanagaraju Ponnusamy, Hongwei Ren, Graham P. Taylor, Lucy B. M. Cook, Anastasios Karadimitris
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
T cell lymphoma
adult T cell leukaemia/lymphoma
ATL
human T cell leukaemia virus type-1
human T cell lymphotropic virus type-1 (HTLV-1)
chimeric antigen receptor (CAR) T-cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1118681/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1118681/full

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