Investigation of intermediate CAG alleles of the HTT in the general population of Rio de Janeiro, Brazil, in comparison with a sample of Huntington disease‐affected families
Abstract Background Huntington disease (HD) (MIM: 143100) is a severe autosomal dominant neurodegenerative disease caused by the expansion of CAG trinucleotides (>35) in the HTT. Objective To investigate the frequency of intermediate CAG alleles (IAs) in individuals residing in Rio de Janeiro cit...
| Main Authors: | , , , |
|---|---|
| 格式: | 文件 |
| 语言: | English |
| 出版: |
Wiley
2020-04-01
|
| 丛编: | Molecular Genetics & Genomic Medicine |
| 主题: | |
| 在线阅读: | https://doi.org/10.1002/mgg3.1181 |