Investigation of intermediate CAG alleles of the HTT in the general population of Rio de Janeiro, Brazil, in comparison with a sample of Huntington disease‐affected families

Investigation of intermediate CAG alleles of the HTT in the general population of Rio de Janeiro, Brazil, in comparison with a sample of Huntington disease‐affected families

Abstract Background Huntington disease (HD) (MIM: 143100) is a severe autosomal dominant neurodegenerative disease caused by the expansion of CAG trinucleotides (>35) in the HTT. Objective To investigate the frequency of intermediate CAG alleles (IAs) in individuals residing in Rio de Janeiro cit...

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Bibliographic Details
Main Authors: Thays A. Apolinário, Iane dos Santos daSilva, Luciana de Andrade Agostinho, Carmen L. A. Paiva
Format: Article
Language:English
Published: Wiley 2020-04-01
Series:Molecular Genetics & Genomic Medicine
Subjects:
Brazilian sample
HTT
Huntington disease
intermediate alleles
Online Access:https://doi.org/10.1002/mgg3.1181

Internet

https://doi.org/10.1002/mgg3.1181

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