A Novel Cell-Based Model for a Rare Disease: The Tks4-KO Human Embryonic Stem Cell Line as a Frank-Ter Haar Syndrome Model System

A Novel Cell-Based Model for a Rare Disease: The Tks4-KO Human Embryonic Stem Cell Line as a Frank-Ter Haar Syndrome Model System

Tyrosine kinase substrate with four SH3 domains (Tks4) scaffold protein plays roles in cell migration and podosome formation and regulates systemic mechanisms such as adult bone homeostasis and adipogenesis. Mutations in the Tks4 gene (<i>SH3PXD2b</i>) cause a rare developmental disorder...

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Bibliographic Details
Main Authors: Loretta László, Hédi Maczelka, Tamás Takács, Anita Kurilla, Álmos Tilajka, László Buday, Virag Vas, Ágota Apáti
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
FTHS
Frank-Ter Haar syndrome
CRISPR-Cas9
Tks4
human embryonic stem cells
cell commitment
Online Access:https://www.mdpi.com/1422-0067/23/15/8803

Internet

https://www.mdpi.com/1422-0067/23/15/8803

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