A complex interplay between H2A.Z and HP1 isoforms regulates pericentric heterochromatin

A complex interplay between H2A.Z and HP1 isoforms regulates pericentric heterochromatin

Pericentric heterochromatin (PCH) plays an essential role in the maintenance of genome integrity and alterations in PCH have been linked to cancer and aging. HP1 α, β, and γ, are hallmarks of constitutive heterochromatin that are thought to promote PCH structure through binding to heterochromatin-sp...

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Bibliographic Details
Main Authors: Jessica González, Laia Bosch-Presegué, Anna Marazuela-Duque, Anna Guitart-Solanes, María Espinosa-Alcantud, Agustín F. Fernandez, Jeremy P. Brown, Juan Ausió, Berta N. Vazquez, Prim B. Singh, Mario F. Fraga, Alejandro Vaquero
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
HP1α,β,γ
heterochromatin
H2A.Z
epigenetics
genome stability
H3K9me3
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1293122/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2023.1293122/full

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