Loss of the AE3 Cl-/HCO3- exchanger in mice affects rate-dependent inotropy and stress-related AKT signaling in heart

Loss of the AE3 Cl-/HCO3- exchanger in mice affects rate-dependent inotropy and stress-related AKT signaling in heart

Cl-/HCO3- exchangers are expressed abundantly in cardiac muscle, suggesting that HCO3- extrusion serves an important function in heart. Mice lacking Anion Exchanger Isoform 3 (AE3), a major cardiac Cl-/HCO3- exchanger, appear healthy, but loss of AE3 causes decompensation in a hypertrophic cardiomyo...

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Bibliographic Details
Main Authors: Vikram ePrasad, John N Lorenz, Valerie M Lasko, Michelle L Nieman, Nabeel J Al Moamen, Gary E Shull
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Physiology
Subjects:
Hypertrophy
PKB
protein kinase B
NBCe1
Slc4a3
SERCA2
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00399/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00399/full

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