Preclinical PET Imaging of Granzyme B Shows Promotion of Immunological Response Following Combination Paclitaxel and Immune Checkpoint Inhibition in Triple Negative Breast Cancer

Preclinical PET Imaging of Granzyme B Shows Promotion of Immunological Response Following Combination Paclitaxel and Immune Checkpoint Inhibition in Triple Negative Breast Cancer

Advancements in monitoring and predicting of patient-specific response of triple negative breast cancer (TNBC) to immunotherapy (IMT) with and without chemotherapy are needed. Using granzyme B-specific positron emission tomography (GZP-PET) imaging, we aimed to monitor changes in effector cell activ...

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Bibliographic Details
Main Authors: Tiara S. Napier, Chanelle L. Hunter, Patrick N. Song, Benjamin M. Larimer, Anna G. Sorace
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Pharmaceutics
Subjects:
PET
GZP-PET
tumor microenvironment
immunotherapy
anti-PD-1
anti-CTLA4
Online Access:https://www.mdpi.com/1999-4923/14/2/440

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https://www.mdpi.com/1999-4923/14/2/440

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