Hypothalamus volume mediates the association between adverse childhood experience and PTSD development after adulthood trauma

Abstract The hypothalamus is critical for regulation of the hypothalamic-pituitary-adrenal (HPA) axis and response to stress. Adverse childhood experience (ACE) can affect brain structure, which may contribute to development of posttraumatic stress disorder (PTSD) after subsequent adult trauma. It i...

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Bibliographic Details
Main Authors: Hong Xie, Chia-Hao Shih, Sulaiman D. Aldoohan, John T. Wall, Xin Wang
Format: Article
Language:English
Published: Nature Publishing Group 2023-08-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-023-02576-2