Leishmania infantum modulates host macrophage mitochondrial metabolism by hijacking the SIRT1-AMPK axis.

Leishmania infantum modulates host macrophage mitochondrial metabolism by hijacking the SIRT1-AMPK axis.

Metabolic manipulation of host cells by intracellular pathogens is currently recognized to play an important role in the pathology of infection. Nevertheless, little information is available regarding mitochondrial energy metabolism in Leishmania infected macrophages. Here, we demonstrate that durin...

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Bibliographic Details
Main Authors: Diana Moreira, Vasco Rodrigues, Maria Abengozar, Luis Rivas, Eduardo Rial, Mireille Laforge, Xiaoling Li, Marc Foretz, Benoit Viollet, Jérôme Estaquier, Anabela Cordeiro da Silva, Ricardo Silvestre
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-03-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4349736?pdf=render

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http://europepmc.org/articles/PMC4349736?pdf=render

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