Bisbiguanide analogs induce mitochondrial stress to inhibit lung cancer cell invasion

Bisbiguanide analogs induce mitochondrial stress to inhibit lung cancer cell invasion

Summary: Targeting cancer metabolism to limit cellular energy and metabolite production is an attractive therapeutic approach. Here, we developed analogs of the bisbiguanide, alexidine, to target lung cancer cell metabolism and assess a structure-activity relationship (SAR). The SAR led to the ident...

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Bibliographic Details
Main Authors: Christina M. Knippler, Jamie L. Arnst, Isaac E. Robinson, Veronika Matsuk, Tala O. Khatib, R. Donald Harvey, Mala Shanmugam, Janna K. Mouw, Haian Fu, Thota Ganesh, Adam I. Marcus
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:iScience
Subjects:
Cellular physiology
Cell biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224008137

Internet

http://www.sciencedirect.com/science/article/pii/S2589004224008137

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