Identification and validation of RNA-binding protein SLC3A2 regulates melanocyte ferroptosis in vitiligo by integrated analysis of single-cell and bulk RNA-sequencing

Identification and validation of RNA-binding protein SLC3A2 regulates melanocyte ferroptosis in vitiligo by integrated analysis of single-cell and bulk RNA-sequencing

Abstract Background The pathogenesis of vitiligo remains unclear. The genes encoding vitiligo-related RNA-binding proteins (RBPs) and their underlying pathogenic mechanism have not been determined. Results Single-cell transcriptome sequencing (scRNA-seq) data from the CNCB database was obtained to i...

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Bibliographic Details
Main Authors: Jingzhan Zhang, Fang Xiang, Yuan Ding, Wen Hu, Hongjuan Wang, Xiangyue Zhang, Zixian Lei, Tingting Li, Peng Wang, Xiaojing Kang
Format: Article
Language:English
Published: BMC 2024-03-01
Series:BMC Genomics
Subjects:
Vitiligo
Single-cell sequencing
Bulk RNA sequencing
RNA-binding protein
SLC3A2
Ferroptosis
Online Access:https://doi.org/10.1186/s12864-024-10147-y

Internet

https://doi.org/10.1186/s12864-024-10147-y

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