Interplay between Structure and Charge as a Key to Allosteric Modulation of Human 20S Proteasome by the Basic Fragment of HIV-1 Tat Protein.

Interplay between Structure and Charge as a Key to Allosteric Modulation of Human 20S Proteasome by the Basic Fragment of HIV-1 Tat Protein.

The proteasome is a giant protease responsible for degradation of the majority of cytosolic proteins. Competitive inhibitors of the proteasome are used against aggressive blood cancers. However, broadening the use of proteasome-targeting drugs requires new mechanistic approaches to the enzyme's...

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Bibliographic Details
Main Authors: Przemysław Karpowicz, Paweł A Osmulski, Julia Witkowska, Emilia Sikorska, Małgorzata Giżyńska, Agnieszka Belczyk-Ciesielska, Maria E Gaczynska, Elżbieta Jankowska
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4648528?pdf=render

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http://europepmc.org/articles/PMC4648528?pdf=render

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