A Role for Presenilin 1 in Regulating the Delivery of Amyloid Precursor Protein to the Cell Surface

A Role for Presenilin 1 in Regulating the Delivery of Amyloid Precursor Protein to the Cell Surface

Presenilin 1 (PS1) and presenilin 2 play a critical role in the γ-secretase processing of amyloid precursor protein (APP) and Notch1. Here, we investigate maturation and intracellular trafficking of APP and other membrane proteins in cells expressing an experimental PS1 deletion mutant (ΔM1,2). Stab...

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Bibliographic Details
Main Authors: Jae Yoon Leem, Carlos A. Saura, Claus Pietrzik, John Christianson, Christian Wanamaker, LaShaunda T. King, Margaret L. Veselits, Taisuke Tomita, Laura Gasparini, Takeshi Iwatsubo, Huaxi Xu, William N. Green, Edward H. Koo, Gopal Thinakaran
Format: Article
Language:English
Published: Elsevier 2002-10-01
Series:Neurobiology of Disease
Subjects:
PS1
APP
nicastrin
γ-secretase
acetylcholine receptors
Alzheimer's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996102905462

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http://www.sciencedirect.com/science/article/pii/S0969996102905462

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