Metabolomic Alterations Do Not Induce Metabolic Burden in the Industrial Yeast M2n[pBKD2-Pccbgl1]-C1 Engineered by Multiple δ-Integration of a Fungal β-Glucosidase Gene

Metabolomic Alterations Do Not Induce Metabolic Burden in the Industrial Yeast M2n[pBKD2-Pccbgl1]-C1 Engineered by Multiple δ-Integration of a Fungal β-Glucosidase Gene

In the lignocellulosic yeast development, metabolic burden relates to redirection of resources from regular cellular activities toward the needs created by recombinant protein production. As a result, growth parameters may be greatly affected. Noteworthy, Saccharomyces cerevisiae M2n[pBKD2-Pccbgl1]-...

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Bibliographic Details
Main Authors: Lorenzo Favaro, Lorenzo Cagnin, Laura Corte, Luca Roscini, Fabio De Pascale, Laura Treu, Stefano Campanaro, Marina Basaglia, Willem H. van Zyl, Sergio Casella, Gianluigi Cardinali
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
lignocellulosic ethanol
metabolic burden
metabolomic fingerprint
Fourier transform infrared spectroscopy
stress response
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2019.00376/full

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https://www.frontiersin.org/article/10.3389/fbioe.2019.00376/full

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