Thrombus-specific/responsive biomimetic nanomedicine for spatiotemporal thrombolysis and alleviation of myocardial ischemia/reperfusion injury

Thrombus-specific/responsive biomimetic nanomedicine for spatiotemporal thrombolysis and alleviation of myocardial ischemia/reperfusion injury

Abstract Acute myocardial infarction (AMI) is usually caused by coronary thrombosis. However, the short half-life, lack of targetability and inevitable ischemia/reperfusion injury secondary to revascularization, which characterizes tissue plasminogen activator (tPA) limit its thrombolytic efficacy f...

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Bibliographic Details
Main Authors: Xiaoyu Guo, Ting Hong, Jie Zang, Rongjiao Shao, Xumin Hou, Kai Wang, Weizhuo Liu, Fan Su, Bin He
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Nanobiotechnology
Subjects:
Myocardial infarction
Ischemia/reperfusion injury
Mitochondrial protection
pH responsive nanomedicine
Platelet biomimetics
Online Access:https://doi.org/10.1186/s12951-022-01686-1

Internet

https://doi.org/10.1186/s12951-022-01686-1

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