Biological Role of Pazopanib and Sunitinib Aldehyde Derivatives in Drug-Induced Liver Injury

Biological Role of Pazopanib and Sunitinib Aldehyde Derivatives in Drug-Induced Liver Injury

Tyrosine kinase inhibitors pazopanib and sunitinib are both used to treat advanced renal cell carcinoma but expose patients to an increased risk of hepatotoxicity. We have previously identified two aldehyde derivatives for pazopanib and sunitinib (P-CHO and S-CHO, respectively) in liver microsomes....

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Bibliographic Details
Main Authors: Maud Maillard, Cécile Arellano, Christelle Vachoux, Christine Chevreau, Nicolas J. Cabaton, Frédéric Pont, Nathalie Saint-Laurent, Thierry Lafont, Etienne Chatelut, Fabienne Thomas
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Metabolites
Subjects:
aldehyde
hepatotoxicity
pazopanib
reactive metabolites
sunitinib
Online Access:https://www.mdpi.com/2218-1989/12/9/852

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https://www.mdpi.com/2218-1989/12/9/852

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