Computational modeling of AMPK and mTOR crosstalk in glutamatergic synapse calcium signaling

Abstract Neuronal energy consumption is vital for information processing and memory formation in synapses. The brain consists of just 2% of the human body’s mass, but consumes almost 20% of the body’s energy budget. Most of this energy is attributed to active transport in ion signaling, with calcium...

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Bibliographic Details
Main Authors: A. Leung, P. Rangamani
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:npj Systems Biology and Applications
Online Access:https://doi.org/10.1038/s41540-023-00295-4