Bacteria employ lysine acetylation of transcriptional regulators to adapt gene expression to cellular metabolism

Bacteria employ lysine acetylation of transcriptional regulators to adapt gene expression to cellular metabolism

Abstract The Escherichia coli TetR-related transcriptional regulator RutR is involved in the coordination of pyrimidine and purine metabolism. Here we report that lysine acetylation modulates RutR function. Applying the genetic code expansion concept, we produced site-specifically lysine-acetylated...

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Bibliographic Details
Main Authors: Magdalena Kremer, Sabrina Schulze, Nadja Eisenbruch, Felix Nagel, Robert Vogt, Leona Berndt, Babett Dörre, Gottfried J. Palm, Jens Hoppen, Britta Girbardt, Dirk Albrecht, Susanne Sievers, Mihaela Delcea, Ulrich Baumann, Karin Schnetz, Michael Lammers
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46039-8

Internet

https://doi.org/10.1038/s41467-024-46039-8

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